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The Mechanisms of Muscle Hypertrophy

Increasing lean body mass is a common goal for many of our personal training clients who come to us to learn how to engage in resistance training. Bodybuilders and powerlifters exemplify two distinct training styles, yet both groups display impressive muscle development. This raises the question: which method is superior for hypertrophy?

By examining the mechanisms of muscle hypertrophy—mechanical tension, muscle damage, and metabolic stress—and their application to resistance training, we can better understand how to optimise muscle growth.

Mechanisms of Muscle Hypertrophy

1. Mechanical Tension

Mechanical tension is generated when muscles contract against resistance, creating a force that stimulates muscle growth. This is a key driver of hypertrophy because it activates muscle protein synthesis pathways. High levels of mechanical tension can be achieved through lifting heavier weights, which is a common practice among powerlifters. This intense focus on mechanical tension contributes to significant muscle gains. Bodybuilders would also use mechanical tension to stimulate hypertrophy, using movements which engage muscles around the mid range where the muscle is able to generate a greater amount of force. We also use this with our clients working at rep ranges from around 6-8 reps.

 

2. Muscle Damage

Muscle damage occurs when muscle fibres experience micro-tears during intense exercise. The body repairs these micro-tears during recovery, leading to muscle growth. Eccentric contractions, such as slowly lowering a weight, are particularly effective at the contribution of muscle damage. While this mechanism contributes to hypertrophy, it must be managed to avoid excessive soreness or injury.

 

3. Metabolic Stress

Metabolic stress is the build-up of metabolites, such as lactate, during higher volumes sets with higher rep ranges using lighter loads. This stress creates a hormonal environment conducive to muscle growth by promoting cellular swelling and the production of growth factors. Bodybuilders often employ techniques that maximise metabolic stress, such as higher repetitions with light -moderate weights and smaller rest periods between sets. We generally use this methods with our personal training clients using exercises that engage muscles within the short to lengthened ranges.

 

Applying the Mechanisms to Resistance Training

To optimise muscle hypertrophy, it is crucial to incorporate elements of all three mechanisms into a well-rounded training program. Here’s how different approaches can be utilized:

1. Moderate Loads and Short Rest Intervals

Bodybuilders typically use moderate loads (around 60-75% of one-rep max) with short rest intervals (30-90 seconds). This approach maximises metabolic stress and induces muscle damage, contributing significantly to muscle growth. Training with moderate loads allows for higher volumes of work, which is beneficial for hypertrophy.

2. High-Intensity Loads and Long Rest Periods

Powerlifters often train with high-intensity loads (85-100% of one-rep max) and long rest periods (2-5 minutes). This method emphasises mechanical tension, as the muscles are subjected to high levels of force. While primarily aimed at enhancing strength, the mechanical tension generated also promotes muscle hypertrophy. Incorporating heavy lifting phases can be beneficial even for those primarily focused on muscle growth.

3. Combined Training Methods

A combined approach can harness the benefits of all hypertrophic mechanisms. For instance, using your compound movements or exercises that work the mid range of a muscle where the muscle has the ability to create more tension from more heavy lifting (to maximise mechanical tension) and utilising exercises that work the shortened and lengthened range of a muscle for higher volume training with short rest intervals (to maximise metabolic stress and muscle damage) can be a very effective method to increase your gains. This variety ensures that all pathways to hypertrophy are stimulated, leading to optimal muscle growth. These are methods we incorporate into many of our programs with our personal training clients, once they can execute the skill of the exercise with good form, then we push the button on these methods by increasing intensities via mechanical tension and metabolic stress.

Maximising muscle hypertrophy requires an understanding of the underlying mechanisms and their application in resistance training. By incorporating mechanical tension, and metabolic stress into a well-rounded training program, you can optimise your muscle growth. Whether through heavy lifting, moderate loads with short rest intervals, or a combination of both, the key is to stimulate all pathways to muscle hypertrophy. With insights from research, our personal trainers can design effective training protocols to help you achieve a strong healthy physique.

 

 

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Finding the Optimal Workout Duration: How Long Should Your Workouts Be?

 

Striking the right balance between an effective workout and a time-efficient routine is essential. To shed light on this topic, we will take a look at various studies conducted on workout durations and provide a summary of the main takeaways. Remember, personal preferences and goals play a significant role, but understanding the scientific evidence can help guide your decision-making process and also give you less room for excuses if you are not currently exercises and taking charge of your health.

 

Study 1: “The Effect of Workout Duration on Strength Gains”

 

In a study published in the Journal of Strength and Conditioning Research, researchers investigated the impact of different workout durations on strength gains. They divided participants into three groups: one group performed 30-minute workouts, another performed 60-minute workouts, and the third group had 90-minute workouts. The study concluded that there were no significant differences in strength gains among the three groups. This suggests that workout duration alone may not be the key factor for strength development.

 

Study 2: “Effects of Workout Duration on Cardiovascular Fitness”

 

A research team at the University of California conducted a study to examine the effects of workout duration on cardiovascular fitness. They assigned participants to two groups: one group performed 30-minute moderate-intensity workouts, and the other group engaged in 60-minute moderate-intensity workouts. The study revealed that both groups experienced significant improvements in cardiovascular fitness. While the 60-minute group demonstrated slightly greater gains, the results indicated that shorter workouts can still yield substantial cardiovascular benefits.

 

Study 3: “Optimal Workout Duration for Fat Loss”

 

In a study published in the International Journal of Obesity, researchers analysed the impact of different workout durations on fat loss. Participants were divided into three groups: one group performed 20-minute high-intensity interval training (HIIT) workouts, another group engaged in 40-minute HIIT workouts, and the third group performed 60-minute steady-state cardio workouts. The findings showed that all three groups experienced significant reductions in body fat percentage, with no significant differences between the durations. This suggests that the intensity of the workout may play a more significant role in fat loss than the duration alone.

 

Study 4: “The Impact of Prolonged Exercise on Hormonal Changes”

 

A study published in the Journal of Endocrinology and Metabolism examined the effects of prolonged exercise on hormonal changes. Male participants performed a high-intensity resistance workout lasting 90 minutes. The study found that after the workout, there was a significant decline in serum testosterone levels and an increase in cortisol levels. These hormonal changes indicated a temporary state of increased catabolism, suggesting that longer workouts may have a negative impact on anabolic hormone balance.

 

Study 5: “Effects of Different Workout Durations on Testosterone and Cortisol Response”

 

A research team conducted a study published in the European Journal of Applied Physiology to investigate the effects of different workout durations on testosterone and cortisol response. Participants performed resistance exercises at varying durations: 30 minutes, 60 minutes, and 90 minutes. The study revealed that the 30-minute workout resulted in a significant increase in testosterone levels without a significant rise in cortisol levels. The 90-minute workout led to a decline in testosterone levels and an increase in cortisol levels. These findings suggest that longer workouts may disrupt the balance of anabolic and catabolic hormones.

 

Main Takeaways:

 

  1. Workout duration alone is not the sole determinant of strength gains. Focus on intensity, proper form, and progressive overload for optimal results.
  2. Both shorter and longer workouts can improve cardiovascular fitness. The key is to maintain a consistent level of intensity.
  3. Fat loss can be achieved with various workout durations. High-intensity exercises, such as HIIT, may be more effective for fat loss than steady-state cardio.
  4. Prolonged exercise sessions, especially high-intensity workouts lasting 90 minutes or more, can lead to a decline in serum testosterone levels.
  5. Longer workouts may result in an increase in cortisol levels, indicating a potential shift towards a catabolic state.
  6. Shorter workout durations, such as 30 minutes, may promote a favorable hormonal response with an increase in testosterone levels and minimal changes in cortisol levels.

 

Determining the ideal workout duration depends on individual preferences, goals, and available time. This also eliminates the excuse of ‘ I don’t have time to exercise’ as we all have 30 mins in our day. While the studies presented above provide insights into the effects of different workout durations, it is important to consider other factors such as exercise intensity, consistency, and recovery. A well-rounded fitness routine that incorporates a mix of strength training, cardiovascular exercises, and flexibility work is generally recommended. Ultimately, the best workout duration is the one that you can keep consistent, motivated, engaged, and helps you achieve your fitness goals.

How Much Does Muscle Growth Differ Between Lifters?

Reference to the Study:

Hubal et. al. (2005). Variability in Muscle Size and Strength Gain After Unilateral Resistance Training. MED SPORTS EXERC.

 

 

Details of the Study:

 

  • 585 untrained adults performed the same arm training routine for 12 weeks.

 

  • Most lifters experienced around a 10-20% increase in cross-sectional area, but there was extreme responses on either end of the spectrum.

 

  • A small number of individuals experienced no detectable muscle growth (with some even seeing losses in muscle size).

 

  • On the other hand, a small number of individuals saw increases in biceps cross-sectional area of greater than 50%.

 

  • As with most biological traits, the response to resistance training generally follows a bell-curve relationship. This means that most people see an ‘average’ muscle growth response, but a small percentage of people experience extremely more/less growth than average.

 

 

Applications to training:

 

  • This study supports the idea of the importance of an individualised plan in order to optimise muscle growth in each person.

 

  • Furthermore, it is unavoidable that some people will find it significantly easier to add muscle more than others, rendering comparison between peers futile. If you want to progress, then track your progression against yourself.

 

  • Ultimately having a personal coach who has the skills to guide you on how to execute your exercises correctly to get the most out of each exercise will put you in the best position to see results with your hypertrophy goals from your training in the gym.

Pre-Fatigue Training vs Traditional Sets on muscle growth

 

 

Reference of the Study: Trinidade et. al. (2019). Effects of Pre-Exhaustion Versus Traditional Resistance Training on Training Volume, Maximal Strength and Quadriceps Hypertrophy FRONT PHYSIOL

 

 

Details of the Study:

 

  • Trainees performed 3 sets of leg press to failure 75% 1RM, 2x per week, for 9 weeks in total.

 

  • One group performed 1 set of leg extensions before the leg press (pre-fatigue group), while another group performed the leg press training in a non-fatigued state (traditional training group).

 

  • It was found that both groups saw significant muscle growth of all quad muscles, with no notable differences between groups.

 

  • This study suggests that when taking each set close to failure, pre-fatiguing a muscle can achieve similar muscle growth compared with traditional training, with no additional benefit.

 

  • This is despite the fact that lifting performance (load lifted), on the leg press for the pre-fatigue group was significantly affected.

 

 

Real World Application:

 

  • Pre-Fatiguing the muscles provides an opportunity to gain the same muscle growth as traditional training, with lighter loads and less repetitions, thereby minimising joint stress.

 

  • Therefore, this could be particularly useful for people returning to the gym after rehabilitating certain joint injuries.

Load vs Rep Progression

 

 

Reference:

Plotkin et. al. (2022) Progressive Overload Without Progressing the Load? The Effects of Load or Repetition Progression on Muscular Adaptations. PERJ.

 

Details of the Study:

 

  • Trainees performed the same lower-body workout 2x per week for 8 weeks, taking all sets to failure.

 

  • One group lifted within the 8-12 rep range and attempted to increase the load over time, still sticking to this rep range.

 

  • The other group also lifted within the 8-12 rep range initially. However they aimed to perform more reps overtime whilst maintaining the same load.

 

Results:

 

  • It was found that both groups saw increases in muscle thickness of all muscles measured, with no notable trends favouring either condition.

 

  • Furthermore, changes in lean mass of the legs were similar between groups.

 

  • This supports the main know drivers of hypertrophy are mechanical tension and metabolic stress are both great for hypertrophy.

 

Real World Application:

  • This study suggests that progression via load or reps results in similar outcomes, as long as the set is taken to failure. Therefore, if muscle growth is the aim then proximity to failure should be prioritized.

 

  • Once you know you can train to failure successfully and it comes the decision to either up the weight or increase reps. Exercise execution is vital for all lifts and movements it would be useful to hire a personal trainer to coach you on exercise execution.

 

  • A useful strategy would be to perform your compound more mid range movements with the progression of load and your isolation movements towards the shortened and lengthened ranges of the muscle towards higher rep ranges.

Does Strength Training Potentiate Hypertrophy?

Study Reference: Carvalho et. al. (2021) is stronger better? Influence of a strength phase followed by a hypertrophy phase on muscular adaptations in resistance trained men. RES SPORTS MED

 

Study Details:

 

  • Men with an average training age of 4-5 years in the gym performed 4 sets of squats and leg press training 3x per week for 8 weeks

 

  • One group lifted in the 8-12 rep range throughout the entire 8 week programme (hypertrophy only training)

 

  • The other group lifted in the 1-3 rep range for the first 3 weeks, before lifting in the 8-12 rep range for the remaining 5 weeks (strength and hypertrophy training)

 

  • After 3 weeks, the hypertrophy group saw greater quad growth compared to the strength + hypertrophy group- as expected.

 

  • However, at the end of the 8 weeks, the strength + hypertrophy group saw superior growth compared to the hypertrophy only group.

 

Real world Applications:

 

  • The study supports the idea that, if you want to maximise muscle growth, then including a short strength phase prior to a hypertrophy phase may be beneficial.

 

  • However, there are plenty of other studies that show that a strength phase prior to a hypertrophy block shows no additional benefits. Therefore, it’s important to note that more research is required before this becomes reliable.

 

Are Eccentrics more important for Hypertrophy?

Reference to Study: Sato et. al. (2022). Comparison between concentric-only, eccentric-only and concentric-eccentric resistance training of the elbow flexors for their effects on muscle strength and hypertrophy. EUR J APPL PHYSIOL

 

Details of the Study:

 

  • Trainees performed 3×10 bicep curls 2x per week for 5 weeks

 

  • 1 group only performed the concentric portion, another group only performed the eccentric portion and the last group performed both concentric and eccentric portions of the bicep curl.

 

  • Note: The total volume load (weight x number of contractions) was double for the concentric+eccentric group.

 

  • Despite this difference in load, it was found that biceps growth was similar between the concentric+eccentric group & the eccentric only group, whilst the concentric only group saw significantly less group.

 

  • Therefore, the study supports the idea that the eccentric portion of the contraction is more important for growth

 

 

Real world application:

  • Many people chasing muscle growth often rush the eccentric portion of lifts, allowing gravity to take the weight down instead of keeping the muscle under as much tension as they could to control the weight. Therefore, this study is part of the growing evidence why this is highly suboptimal for their training goal.

Short vs Long rest periods for Muscle Growth

Reference: Schoenfield et. al. (2016) Longer Interset Rest Periods Enhance Muscle Strength and Hypertrophy in Resistance Trained Men.

 

Information on the study:

 

  • Trainees with at least 6 months resistance training experience were split into 2 groups

 

  • Both groups performed 7 compound lifts, for 3 sets of 8-12 reps, 3x per week, for 8 weeks

 

  • 1 group rested for 1 minute between sets, while the other rested for 3 minutes between sets

 

 

  • It was found that the longer rest group saw superior gains in all muscle groups when compared to the shorter rest group.

 

  • This supports the idea that longer rest periods are superior for hypertrophy

 

 

Application to real world:

  • With longer rest periods come longer overall sessions durations, unless you cut overall volume.
  • Overall volume has been shown to be a significant factor in muscle hypertrophy
  • Therefore, it may be worth only applying these long rest periods if you have the extra time free in your schedule to allow you to do so.

Is scale weight an accurate way to track progress?

When people embark on a fitness journey, whether that be to lose body fat or gain muscle mass, the common tool to track their progress people use is how much the number on the scales changes over time. However, is this the most accurate way to track progress towards body composition goals? Just like most questions relating to health and fitness, the answer is- it depends.

 

The first thing to remember is that scale weight is the total weight of all the tissues in your body and not just muscle and fat. Therefore, it is not the most accurate measurement when it comes to measuring body composition. Other methods include skin fold callipers, a cheap tool which measures body fat percentage. However, despite its low cost, the skill needed to take an accurate measurement makes this a fairly inaccessible method of measuring body composition. The gold standard of body composition measurement in a DEXA Scanner. Although, this is a very expensive piece of equipment, only really seen in medical facilities due to its use in also identifying bone density and helping diagnose patients with osteoporosis. Due to other methods being inaccessible, scales are by far the most common tool used by the general population to assess progress in their body composition goals, so what can be done to ensure you are getting the most reliable and accurate changes to body fat and muscle as you can with scales?

 

Any tool is only effective when you know how to use it and scales are no different. Weighing yourself on Monday at 7am and then again on Sunday at 8pm will not give an accurate measurement for how your weight has changed over the course of the week, due to factors that will be discussed in this article. Therefore, if you are to use scales accurately, I would recommend taking daily measurements, first thing in the morning each day and then calculating the mean average each week and compare each week’s average from the last, to get a more accurate measurement of how much your weight is changing due to changes to fat or muscle tissue.

 

So, what factors can influence the weight on the scales besides from muscle and fat tissue? Firstly, there’s water retention. The amount of water our bodies hold will hold will change throughout the day, as well as day by day. Reasons for this include carbohydrate and sodium intake, which cause our bodies to hold more water- not add on fat tissue (a common misconception in, the case of carbohydrates, spread by the misinformed and keto zealots). Therefore, if your diet is more heavily carbohydrate based for a few days, then you may add some weight. However, this will be due to the added water retention from an increased intake of carbohydrates, not an added amount of fat tissue.

 

Next, there’s the amount of food you are currently digesting. First thing in the morning, is when you have the least food in your digestive system as it will have been 9-10 hours since your last meal. Therefore, food being digested cannot influence your scale weight, unlike if you weighed yourself shortly after a meal.

 

Besides from keeping these variables at bay, what else can be done to improve the reliability and accuracy of scales measuring body composition? Firstly, you could also use a measuring tape and measure your Hip to Waist Ratio. This is productive because most people hold the majority of fat around their Waist area. Therefore, if you are trying to gain muscle mass and you put yourself in a calorie surplus and put on weight, you may believe you are getting closer to your goal. However, if you take measurements are realise your Waist measurement is increasing at a faster rate than your Hips, then this indicates you are putting on fat faster than muscle mass. This information can then lead to you making productive changes to your training and/or nutrition.

 

Next, it’s important to ensure you are setting yourself up for success. One way to do this is to ensure you are consuming enough protein and tracking it. Ensuring adequate protein intake with a suitable resistance training programme and sleep will ensure that any weight loss will not be due to loss of muscle mass. Alternatively, when gaining muscle, will ensure you are adding as much muscle mass as you can in the calorie surplus you are in.

 

In conclusion, scales are far from perfect when it comes to measuring body composition goals. However, with the correct information, it can be a very useful tool to help you stay on track when pursuing your goals.

 

Fast Bulk vs Slow Bulk

The Study: Garthe et. al. (2013), Effect of Nutritional Intervention on Body Composition And Performance In Elite Athletics. EUR J SPORT SCI

 

 

  • 39 elite athletes recruited for the study and split into 2 groups.

 

  • For 8-12 weeks (dependant on length of their off-season) One group completed a fast bulk (high calorie surplus) and the another completed a slow bulk with a much more moderate calorie surplus. Both groups had adequate protein in their diets to facilitate hypertrophy.

 

  • The higher calorie group gained weight at a rate of 0.4% of Bodyweight per week whilst the moderate calorie group gained weight at a rate of 0.2% of bodyweight per week.

 

  • Unsurprisingly, the fast bulk group gained more than twice the amount of bodyweight than the slow bulk group

 

  • However, there was only a small difference in lean mass (High calorie group averaged 1.7kg lean mass gained whilst moderate calorie group 1.2kg)

 

  • Also, the fast bulk group put on 5 times as much body fat (1.1kg vs 0.2kg) compared to the slower bulk group.

 

  • This study supports the idea that a smaller calorie surplus is better for maintaining a low body fat percentage in a bulk. However, if muscle gain is the sole goal, like open weight category powerlifters, then a faster bulk may be more beneficial.